Genpac Interaction DB
ex.)MAPK1, Actin, Fluorouracil,
thrombocytopenia
Powered by Nalapro technologies
Hello Subio
Customer List
User Survey
Filtering by Language:
  • Japanese
  • English

Forum

Apoptosis: No Transcription Required

After demonstrating that IRF-3 was necessary for apoptosis of either infected cells or cells exposed to polyinosine-polycytosine [poly(I:C)] by analyzing specific knockout mouse embryo fibroblasts, the authors showed that poly(I:C)- or virus-induced apoptosis required RLH RIG-1, MAVS, TRAF3, TRAF2, TRAF6, and TBK1. Surprisingly, reconstitution of IRF-3–deficient cells with IRF-3 mutants that lacked transcriptional activity restored apoptosis in response to poly(I:C).

http://stke.sciencemag.org/cgi/content/abstract/sigtrans;3/124/ec161

Comments

No comment.