Genotype to Phenotype: A Complex Problem
- By: tabukov@subio
- Date: 2010-05-12 16:17:12
http://www.sciencemag.org/cgi/content/abstract/328/5977/469
[Abstract]
We generated a high-resolution whole-genome sequence and individually deleted 5100 genes in {Sigma}1278b, a Saccharomyces cerevisiae strain closely related to reference strain S288c. Similar to the variation between human individuals, {Sigma}1278b and S288c average 3.2 single-nucleotide polymorphisms per kilobase. A genome-wide comparison of deletion mutant phenotypes identified a subset of genes that were conditionally essential by strain, including 44 essential genes unique to {Sigma}1278b and 13 unique to S288c. Genetic analysis indicates the conditional phenotype was most often governed by complex genetic interactions, depending on multiple background-specific modifiers. Our comprehensive analysis suggests that the presence of a complex set of modifiers will often underlie the phenotypic differences between individuals.
I think that this paper introduced a new aspect into genetics research. What does gene function mean?
No comment.