Gene expression profile of androgen modulated genes in the murine fetal developing lung.
- By: tayac@subio
- Date: 2010-01-20 17:06:50
Bresson E et al.
Reprod Biol Endocrinol. 2010 Jan 8;8(1):2. [Epub ahead of print]
http://www.rbej.com/content/pdf/1477-7827-8-2.pdf
ABSTRACT:
BACKGROUND: Accumulating evidences suggest that sex affects lung development. Indeed, a higher incidence of respiratory distress syndrome is observed in male compared to female preterm neonates at comparable developmental stage and experimental studies demonstrated an androgen-related delay in male lung maturation. However, the precise mechanisms underlying these deleterious effects of androgens in lung maturation are only partially understood.
....
CONCLUSION: Our results show clearly that there is a real delay in lung maturation between male and female in this period, the latter pursuing already lung maturation while the proper is not yet fully engaged in the differentiation processes at GD17. In addition, this study provides a list of genes which are under the control of androgens within the lung at the moment of surge of surfactant production in murine fetal lung.
Microarray data of this study (GSE18135) is available with Subio Series Archive (ssa) file at;
http://www.box.net/shared/2e9sx38b0o
You can easily import the .ssa file into Subio Platform and view it.
Subio Platform is a free omics data browser for biologists.
Windows and Mac versions are available.
https://www.subio.jp/products/download
Instruction movie for importing .ssa file
http://www.screencast.com/t/OTM2MDE1YTg
No comment.