The dynamic architecture of the metabolic switch in Streptomyces coelicolor.
- By: tayac@subio
- Date: 2010-01-20 13:44:52
Nieselt K et al.
BMC Genomics. 2010 Jan 6;11(1):10. [Epub ahead of print]
http://www.biomedcentral.com/content/pdf/1471-2164-11-10.pdf
ABSTRACT:
BACKGROUND: During the lifetime of a fermenter culture, the soil bacterium S. coelicolor undergoes a major metabolic switch from exponential growth to antibiotic production. We have studied gene expression patterns during this switch, using a specifically designed Affymetrix genechip and a high-resolution time-series of fermenter-grown samples.
...
CONCLUSIONS: Our study provides the first detailed insights into the complex sequence of early regulatory events during and preceding the major metabolic switch in S. coelicolor, which will form the starting point for future attempts at engineering antibiotic production in a biotechnological setting.
Microarray data of this study deposited on GEO (GSE18489) prepared to Subio Series Archive (ssa) file at;
https://www.sugarsync.com/pf/D664412_76_8682886167
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