Rapamycin Response in Tumorigenic and Non-Tumorigenic Hepatic Cell Lines
- By: tayac@subio
- Date: 2010-01-19 17:14:01
Jimenez RH, Boylan JM, Lee J-S, Francesconi M, Castellani G, et al. (2009) PLoS ONE 4(10): e7373. doi:10.1371/journal.pone.0007373
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007373
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We conclude that the mechanisms of rapamycin resistance in hepatic cells involve alterations of signaling downstream from mTOR and that the mechanisms are highly heterogeneous, thus predicting that maintaining or promoting sensitivity will be highly challenging.
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