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Human DNA methylome

Nearly one-quarter of all methylation identified in embryonic stem cells was in a non-CG context, suggesting that embryonic stem cells may use different methylation mechanisms to affect gene regulation. Methylation in non-CG contexts showed enrichment in gene bodies and depletion in protein binding sites and enhancers. Non-CG methylation disappeared upon induced differentiation of the embryonic stem cells, and was restored in induced pluripotent stem cells.

http://www.nature.com/nature/journal/v462/n7271/full/nature08514.html

Genome browser and downloadable data are available from San Diego Epigenome Center.
http://neomorph.salk.edu/human_methylome/

Comments

Time for the epigenome

  • By: tayac@subio
  • Date: 2010-02-04 13:24:10

Editorial of Nature 463, 587 (4 February 2010)

The complexity of genetic regulation is one of the great wonders of nature, but it represents a daunting challenge to unravel. The International Human Epigenome Consortium is an appropriate response.

http://www.nature.com/nature/journal/v463/n7281/full/463587a.html

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